Detail publikace

Analysis of drug residuals in waste water by tandem gas chromatography with mass spectrometric detection

ČÁSLAVSKÝ, J. LACINA, P. VÁVROVÁ, M. MRAVCOVÁ, L.

Originální název

Analysis of drug residuals in waste water by tandem gas chromatography with mass spectrometric detection

Typ

článek ve sborníku ve WoS nebo Scopus

Jazyk

angličtina

Originální abstrakt

This study is focused on the analysis of selected pharmaceuticals from the group of analgesics and sulfonamides in surface and waste water. These compounds are discharged to the sewer systems with human excrements after their administration either unchanged or as various metabolites and conjugates and enter the sewage treatment plants, where they are only partly removed during the cleaning process. Therefore they can be found in the discharged water or in sewage sludge and this way they enter the environment, where they can induce negative effects on organisms in soil and water ecosystems. Liquid chromatography with spectrophotometric or mass spectrometric detection is usually used for the analysis of these compounds. Nevertheless, gas chromatography offers substantially better separation efficiency based on fused silica capillary columns. Mass spectrometric detection with electron ionization enables reliable identification of separated compounds on the base of library searches. The only disadvantage of GC application in this field is usually the necessity of suitable derivatization of drugs in order to increase their volatility. Solid phase extraction was used for the isolation of target analytes from the waste water at influent and effluent of the municipal waste water treatment plant in Brno-Modřice. Orthogonal comprehensive two-dimensional gas chromatography with mass spectrometric detection (GCxGC-TOF MS) was used for their final analysis after derivatization with MSTFA.

Klíčová slova

Waste water, drug residuals, sulfonamides, analgesics, gas chromatography, mass spectrometry

Autoři

ČÁSLAVSKÝ, J.; LACINA, P.; VÁVROVÁ, M.; MRAVCOVÁ, L.

Rok RIV

2010

Vydáno

28. 5. 2010

Nakladatel

Universita Pardubice

Místo

Pardubice

ISBN

978-80-7395-282-2

Kniha

Sborník 14. česko-slovenské spektroskopické konference

Edice

1.

Číslo edice

1.

Strany od

D-1

Strany do

D-1

Strany počet

1