Detail publikace

Parametric Deconvolution for Cancer Cells Viscoelasticity Measurements from Quantitative Phase Images

VIČAR, T. GUMULEC, J. KOLÁŘ, R. CHMELÍK, J. NAVRATIL, J. CHMELÍKOVÁ, L. ČMIEL, V. PROVAZNÍK, I. MASAŘÍK, M.

Originální název

Parametric Deconvolution for Cancer Cells Viscoelasticity Measurements from Quantitative Phase Images

Typ

článek ve sborníku ve WoS nebo Scopus

Jazyk

angličtina

Originální abstrakt

In this contribution, we focused on optimising a dynamic flow-based shear stress system to achieve a reliable platform for cell shear modulus (stiffness) and viscosity assessment using quantitative phase imaging. The estimation of cell viscoelastic properties is influenced by distortion of the shear stress waveform, which is caused by the properties of the flow system components (i.e., syringe, flow chamber and tubing). We observed that these components have a significant influence on the measured cell viscoelastic characteristics. To suppress this effect, we applied a correction method utilizing parametric deconvolution of the flow system's optimized impulse response. Achieved results were compared with the direct fitting of the Kelvin-Voigt viscoelastic model and the basic steady-state model. The results showed that our novel parametric deconvolution approach is more robust and provides a more reliable estimation of viscosity with respect to changes in the syringe's compliance compared to Kelvin-Voigt model.

Klíčová slova

shear stress;quantitative phase imaging;viscoelastic model

Autoři

VIČAR, T.; GUMULEC, J.; KOLÁŘ, R.; CHMELÍK, J.; NAVRATIL, J.; CHMELÍKOVÁ, L.; ČMIEL, V.; PROVAZNÍK, I.; MASAŘÍK, M.

Vydáno

18. 11. 2021

Nakladatel

IEEE

Místo

345 E 47TH ST, NEW YORK, NY 10017 USA

ISBN

978-1-7281-1179-7

Kniha

IEEE Engineering in Medicine and Biology Society Conference Proceedings

ISSN

1557-170X

Periodikum

Proceedings IEEE EMBC

Stát

Spojené státy americké

Strany od

439

Strany do

442

Strany počet

4

URL

https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=9630524

BibTex

@inproceedings{BUT173255,
  author="Tomáš {Vičar} and Jaromír {Gumulec} and Radim {Kolář} and Jiří {Chmelík} and Jiri {Navratil} and Larisa {Chmelíková} and Vratislav {Čmiel} and Valentine {Provazník} and Michal {Masařík}",
  title="Parametric Deconvolution for Cancer Cells Viscoelasticity Measurements from Quantitative Phase Images",
  booktitle="IEEE Engineering in Medicine and Biology Society Conference Proceedings",
  year="2021",
  journal="Proceedings IEEE EMBC",
  pages="439--442",
  publisher="IEEE",
  address="345 E 47TH ST, NEW YORK, NY 10017 USA",
  doi="10.1109/EMBC46164.2021.9630524",
  isbn="978-1-7281-1179-7",
  issn="1557-170X",
  url="https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=9630524"
}