Detail publikace

Development and Characterization of Natural Product Derived Macromolecules Based Interpenetrating Polymer Network for Therapeutic Drug Targeting

BISWAS, A. MONDAL, S. KUMAR DAS, S. BOSE, A. THOMAS, S. GHOSAL, K. ROY, S. PROVAZNÍK, I.

Originální název

Development and Characterization of Natural Product Derived Macromolecules Based Interpenetrating Polymer Network for Therapeutic Drug Targeting

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Interpenetrating polymer network (IPN)-based bead formulations were exploited by cross-linking different hydrophilic polymers in different combinations and at different ratios. Polyvinyl alcohol, xanthan gum, guar gum, gellan gum, and sodium alginate (Na-alginate) were used in this work as hydrophilic polymers to enhance the solubility of diclofenac sodium and also to target the delivery at preferred locations. IPN beads based on polysaccharides were prepared by the ionic gelation method. Differential scanning calorimetry, powder X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy data showed that the IPN microbeads solubilized and encapsulated the drug within the network. We found over 83% encapsulation efficiency of the drug delivery system for the drug, and this efficiency increased with the concentration of the polymer. Ex vivo experiments using the goat intestine revealed that the IPN microbeads were able to adhere to the intestinal epithelium, a mucoadhesive behavior that could be beneficial to the drug pharmacokinetics, while in vitro experiments in phosphate buffer showed that the IPN enabled significant drug release. We believe that these IPN microbeads are an excellent drug delivery system to solubilize drug molecules and ensure adhesion to the intestinal wall, thereby localizing the drug release to enhance bioavailability of poorly soluble drugs.

Klíčová slova

Natural Products, Interpenetrating polymer network, Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC).

Autoři

BISWAS, A.; MONDAL, S.; KUMAR DAS, S.; BOSE, A.; THOMAS, S.; GHOSAL, K.; ROY, S.; PROVAZNÍK, I.

Vydáno

25. 10. 2021

Nakladatel

American Chemical Society

Místo

New York

ISSN

2470-1343

Periodikum

ACS OMEGA

Ročník

6

Číslo

43

Stát

Spojené státy americké

Strany od

28699

Strany do

28709

Strany počet

10

URL

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567264/

Plný text v Digitální knihovně

http://hdl.handle.net/11012/203079

BibTex

@article{BUT173140,
  author="Avirup {Biswas} and Sancharee {Mondal} and Sanjoy {Kumar Das} and Anindya {Bose} and Sabu {Thomas} and Kajal {Ghosal} and Sudeep {Roy} and Valentine {Provazník}",
  title="Development and Characterization of Natural Product Derived Macromolecules Based Interpenetrating Polymer Network for Therapeutic Drug Targeting",
  journal="ACS OMEGA",
  year="2021",
  volume="6",
  number="43",
  pages="28699--28709",
  doi="10.1021/acsomega.1c03363",
  issn="2470-1343",
  url="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567264/"
}