Detail publikace

Ex-vivo biomechanical testing of pig femur diaphysis B type fracture fixed by novel biodegradable bone glue

KRTIČKA, M. MICHLOVSKÁ, L. NEKUDA, V. POLÁČEK, P. VALOVÁ, K. ŽÍDEK, J. KAISER, J. ZIKMUND, T. VOJTOVÁ, L.

Originální název

Ex-vivo biomechanical testing of pig femur diaphysis B type fracture fixed by novel biodegradable bone glue

Anglický název

Ex-vivo biomechanical testing of pig femur diaphysis B type fracture fixed by novel biodegradable bone glue

Jazyk

en

Originální abstrakt

This study aimed to answer the question whether our newly developed injectable biodegradable “self-setting” polymer composite as a bone adhesive is a good “bone-glue” candidate to efficiently fix comminuted fractures of pig femoral bone used as an ex-vivo experimental model. Mechanical properties of the adhesive prepared from α-tricalcium phosphate (TCP) powder and thermosensitive copolymer were optimized by selecting the appropriate composition with adhesion enhancers based on dopamine and sodium iodinate. Setting time and injectability were controlled by rheology. Ex-vivo experiments of fixed pig bones were provided in terms of either the three-point bending test of bending wedge type fractured pig femurs (with LCP) or the axial compression test of 45° oblique fractured femurs (without LCP). Fractured bones glued with optimized adhesive before and after bending tests were imaged by X-ray microtomography (μCT).

Anglický abstrakt

This study aimed to answer the question whether our newly developed injectable biodegradable “self-setting” polymer composite as a bone adhesive is a good “bone-glue” candidate to efficiently fix comminuted fractures of pig femoral bone used as an ex-vivo experimental model. Mechanical properties of the adhesive prepared from α-tricalcium phosphate (TCP) powder and thermosensitive copolymer were optimized by selecting the appropriate composition with adhesion enhancers based on dopamine and sodium iodinate. Setting time and injectability were controlled by rheology. Ex-vivo experiments of fixed pig bones were provided in terms of either the three-point bending test of bending wedge type fractured pig femurs (with LCP) or the axial compression test of 45° oblique fractured femurs (without LCP). Fractured bones glued with optimized adhesive before and after bending tests were imaged by X-ray microtomography (μCT).

Dokumenty

BibTex


@article{BUT170217,
  author="Milan {Krtička} and Lenka {Michlovská} and Vladimír {Nekuda} and Petr {Poláček} and Kristýna {Hlináková} and Jan {Žídek} and Jozef {Kaiser} and Tomáš {Zikmund} and Lucy {Vojtová}",
  title="Ex-vivo biomechanical testing of pig femur diaphysis B type fracture fixed by novel biodegradable bone glue",
  annote="This study aimed to answer the question whether our newly developed injectable biodegradable “self-setting” polymer composite as a bone adhesive is a good “bone-glue” candidate to efficiently fix comminuted fractures of pig femoral bone used as an ex-vivo experimental model. Mechanical properties of the adhesive prepared from α-tricalcium phosphate (TCP) powder and thermosensitive copolymer were optimized by selecting the appropriate composition with adhesion enhancers based on dopamine and sodium iodinate. Setting time and injectability were controlled by rheology. Ex-vivo experiments of fixed pig bones were provided in terms of either the three-point bending test of bending wedge type fractured pig femurs (with LCP) or the axial compression test of 45° oblique fractured femurs (without LCP). Fractured bones glued with optimized adhesive before and after bending tests were imaged by X-ray microtomography (μCT).",
  address="Elsevier Ltd",
  chapter="170217",
  doi="10.1016/j.jmbbm.2020.104249",
  howpublished="online",
  institution="Elsevier Ltd",
  number="115",
  year="2021",
  month="march",
  pages="1--8",
  publisher="Elsevier Ltd",
  type="journal article in Web of Science"
}