Detail publikace

Plasticized poly(3‑hydroxybutyrate)/poly(d,l‑lactide) blends filled with tricalcium phosphate for FDM 3D printing and their biological properties

MELČOVÁ, V. CHALOUPKOVÁ, K. VOJTOVÁ, L. RAMPICHOVÁ, M.

Originální název

Plasticized poly(3‑hydroxybutyrate)/poly(d,l‑lactide) blends filled with tricalcium phosphate for FDM 3D printing and their biological properties

Anglický název

Plasticized poly(3‑hydroxybutyrate)/poly(d,l‑lactide) blends filled with tricalcium phosphate for FDM 3D printing and their biological properties

Jazyk

en

Originální abstrakt

Additive manufacturing or 3D printing is a production technology capable of producing nearly any desired shape including complex porous structures. Thanks to this, it is often exploited for the man-ufacturing of scaffolds for tissue engineering, a modern approach of regenerative medicine. In this work, we have successfully prepared plasticized poly(3-hydroxybutyrate)/polylactide 70/30 blends modified with bioceramic tricalcium phosphate (13 wt%) and used them for Fused Deposition Modeling 3D printing. Two commercial plasticizers, Citroflex B6 (n-Butyryl tri-n-hexyl citrate) and Syncroflex 3114 (oligomeric adipate ester), in the amount of 12 wt% were used. the materials were firstly subjected to print-ing parameters optimization, afterwards printability, thermal and mechanical testing and as well as series of biological tests in vitrowere conducted. Citroflex plasticizer was proven to be effective in enhancing the processability and mechanical properties of stud-ied biopolymer blend, however the biocompatibility of samples with this citrate-based plasticizer was rather poor. on the other hand, Syncroflex materials showed better warping properties than commercial grade PLA filament and moreover the results of bio-logical tests revealed its potential to be used for stem cell-seeded scaffolds for regenerative medicine of bones

Anglický abstrakt

Additive manufacturing or 3D printing is a production technology capable of producing nearly any desired shape including complex porous structures. Thanks to this, it is often exploited for the man-ufacturing of scaffolds for tissue engineering, a modern approach of regenerative medicine. In this work, we have successfully prepared plasticized poly(3-hydroxybutyrate)/polylactide 70/30 blends modified with bioceramic tricalcium phosphate (13 wt%) and used them for Fused Deposition Modeling 3D printing. Two commercial plasticizers, Citroflex B6 (n-Butyryl tri-n-hexyl citrate) and Syncroflex 3114 (oligomeric adipate ester), in the amount of 12 wt% were used. the materials were firstly subjected to print-ing parameters optimization, afterwards printability, thermal and mechanical testing and as well as series of biological tests in vitrowere conducted. Citroflex plasticizer was proven to be effective in enhancing the processability and mechanical properties of stud-ied biopolymer blend, however the biocompatibility of samples with this citrate-based plasticizer was rather poor. on the other hand, Syncroflex materials showed better warping properties than commercial grade PLA filament and moreover the results of bio-logical tests revealed its potential to be used for stem cell-seeded scaffolds for regenerative medicine of bones

Dokumenty

BibTex


@misc{BUT169253,
  author="Veronika {Melčová} and Kateřina {Chaloupková} and Lucy {Vojtová}",
  title="Plasticized poly(3‑hydroxybutyrate)/poly(d,l‑lactide) blends filled with tricalcium phosphate for FDM 3D printing and their biological properties",
  annote="Additive manufacturing or 3D printing is a production technology capable of producing nearly any desired shape including complex porous structures. Thanks to this, it is often exploited for the man-ufacturing of scaffolds for tissue engineering, a modern approach of  regenerative  medicine.  In  this  work,  we  have  successfully prepared  plasticized  poly(3-hydroxybutyrate)/polylactide  70/30 blends modified with bioceramic tricalcium phosphate (13 wt%) and used them for Fused Deposition Modeling 3D printing. Two commercial plasticizers, Citroflex B6 (n-Butyryl tri-n-hexyl citrate) and  Syncroflex  3114  (oligomeric  adipate  ester),  in  the  amount of 12 wt% were used. the materials were firstly subjected to print-ing parameters optimization, afterwards printability, thermal and mechanical testing and as well as series of biological tests in vitrowere conducted. Citroflex plasticizer was proven to be effective in enhancing the processability and mechanical properties of stud-ied  biopolymer  blend,  however  the  biocompatibility  of  samples with this citrate-based plasticizer was rather poor. on the other hand, Syncroflex materials showed better warping properties than commercial grade PLA filament and moreover the results of bio-logical tests revealed its potential to be used for stem cell-seeded scaffolds for regenerative medicine of bones",
  address="Vysoké učení technické v Brně, Fakulta chemická",
  booktitle="Sborník abstraktů Chemie je živo 2020",
  chapter="169253",
  howpublished="online",
  institution="Vysoké učení technické v Brně, Fakulta chemická",
  year="2020",
  month="november",
  pages="106--107",
  publisher="Vysoké učení technické v Brně, Fakulta chemická",
  type="abstract"
}