Detail publikace

Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage

KAUCKÁ, M. ZIKMUND, T. TESAŘOVÁ, M. GYLLBORG, D. HELLANDER, A. JAROŠ, J. KAISER, J. PETERSEN, J. SZAROWSKA, B. NEWTON, P.T. DYACHUK, V. LI, L. QIAN, H. JOHANSSON, A-S. MISHINA, Y. CURRIE, J. TANAKA, E.M. ERICKSON, A. DUDLEY, A. BRISMAR, H. SOUTHAM, P. COEN, E. CHEN, M. WEINSTEIN, L.S. HAMPL, A. ARENAS, E. CHAGIN, A.S. FRIED, K. ADAMEYKO, I.

Originální název

Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Cartilaginous structures are at the core of embryo growth and shaping before the bone forms. Here we report a novel principle of vertebrate cartilage growth that is based on introducing transversally-oriented clones into pre-existing cartilage. This mechanism of growth uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thickness, a process which might be the evolutionary mechanism underlying adaptations of facial shape. In rod-shaped cartilage structures (Meckel, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns determines the well-defined diameter and resulting rod-like morphology. We were able to alter cartilage shape by experimentally manipulating clonal geometries. Using in silico modeling, we discovered that anisotropic proliferation might explain cartilage bending and groove formation at the macro-scale.

Klíčová slova

cell dynamics, cartilaginous elements, growth, cartilage

Autoři

KAUCKÁ, M.; ZIKMUND, T.; TESAŘOVÁ, M.; GYLLBORG, D.; HELLANDER, A.; JAROŠ, J.; KAISER, J.; PETERSEN, J.; SZAROWSKA, B.; NEWTON, P.T.; DYACHUK, V.; LI, L.; QIAN, H.; JOHANSSON, A-S.; MISHINA, Y.; CURRIE, J.; TANAKA, E.M.; ERICKSON, A.; DUDLEY, A.; BRISMAR, H.; SOUTHAM, P.; COEN, E.; CHEN, M.; WEINSTEIN, L.S.; HAMPL, A.; ARENAS, E.; CHAGIN, A.S.; FRIED, K.; ADAMEYKO, I.

Vydáno

17. 4. 2017

Nakladatel

eLife Sciences Publications

ISSN

2050-084X

Periodikum

eLife

Ročník

6

Číslo

4

Stát

Spojené království Velké Británie a Severního Irska

Strany od

1

Strany do

82

Strany počet

82

URL

https://elifesciences.org/content/6/e25902

Plný text v Digitální knihovně

http://hdl.handle.net/11012/65749

BibTex

@article{BUT134851,
  author="KAUCKÁ, M. and ZIKMUND, T. and TESAŘOVÁ, M. and GYLLBORG, D. and HELLANDER, A. and JAROŠ, J. and KAISER, J. and PETERSEN, J. and SZAROWSKA, B. and NEWTON, P.T. and DYACHUK, V. and LI, L. and QIAN, H. and JOHANSSON, A-S. and MISHINA, Y. and CURRIE, J. and TANAKA, E.M. and ERICKSON, A. and DUDLEY, A. and BRISMAR, H. and SOUTHAM, P. and COEN, E. and CHEN, M. and WEINSTEIN, L.S. and HAMPL, A. and ARENAS, E. and CHAGIN, A.S. and FRIED, K. and ADAMEYKO, I.",
  title="Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage",
  journal="eLife",
  year="2017",
  volume="6",
  number="4",
  pages="1--82",
  doi="10.7554/eLife.25902",
  issn="2050-084X",
  url="https://elifesciences.org/content/6/e25902"
}