Detail publikace

Natural polysaccharide Gum Karaya as novel biomaterial in regenerative medicine

POŠTULKOVÁ, H. VOJTOVÁ, L. JANČÁŘ, J.

Originální název

Natural polysaccharide Gum Karaya as novel biomaterial in regenerative medicine

Anglický název

Natural polysaccharide Gum Karaya as novel biomaterial in regenerative medicine

Jazyk

en

Originální abstrakt

Natural polysaccharides are biodegradable, freely available, relatively cheap and nontoxic materials with great potential in medical applications. The polysaccharide hydrogels supports wound healing by providing moist environment and can be utilized as wound dressing for soft tissue regeneration (e.g. skin burns or ulcers). One suitable candidate is Gum Karaya (GK), anionic polysaccharide containing β-D-galactose, L-rhamnose, β-D-glucuronic acid and D-galacturonic acid. Natural GK is partially acetylated high molecular weight polymer (Mw ≈ 9 mil Da), water insoluble, having high swelling and retention capacity, high viscosity and inherent antimicrobial activity. [1, 2, 3] The objective of this study is to prepare a soluble sample of GK by alkali treatment followed by designing new procedure for GK hydrogel preparation which meets requirements for use as wound healing coverings. Prepared samples were characterized by SEM, FTIR, NMR, TGA, DSC and rheology.

Anglický abstrakt

Natural polysaccharides are biodegradable, freely available, relatively cheap and nontoxic materials with great potential in medical applications. The polysaccharide hydrogels supports wound healing by providing moist environment and can be utilized as wound dressing for soft tissue regeneration (e.g. skin burns or ulcers). One suitable candidate is Gum Karaya (GK), anionic polysaccharide containing β-D-galactose, L-rhamnose, β-D-glucuronic acid and D-galacturonic acid. Natural GK is partially acetylated high molecular weight polymer (Mw ≈ 9 mil Da), water insoluble, having high swelling and retention capacity, high viscosity and inherent antimicrobial activity. [1, 2, 3] The objective of this study is to prepare a soluble sample of GK by alkali treatment followed by designing new procedure for GK hydrogel preparation which meets requirements for use as wound healing coverings. Prepared samples were characterized by SEM, FTIR, NMR, TGA, DSC and rheology.

Dokumenty

BibTex


@misc{BUT115916,
  author="Hana {Poštulková} and Lucy {Vojtová} and Josef {Jančář}",
  title="Natural polysaccharide Gum Karaya as novel biomaterial in regenerative medicine",
  annote="Natural polysaccharides are biodegradable, freely available, relatively cheap and nontoxic materials with great potential in medical applications. The polysaccharide hydrogels supports wound healing by providing moist environment and can be utilized as wound dressing for soft tissue regeneration (e.g. skin burns or ulcers). 
One suitable candidate is Gum Karaya (GK), anionic polysaccharide containing β-D-galactose, L-rhamnose, β-D-glucuronic acid and D-galacturonic acid. Natural GK is partially acetylated high molecular weight polymer (Mw ≈ 9 mil Da), water insoluble, having high swelling and retention capacity, high viscosity and inherent antimicrobial activity. [1, 2, 3]
The objective of this study is to prepare a soluble sample of GK by alkali treatment followed by designing new procedure for GK hydrogel preparation which meets requirements for use as wound healing coverings. Prepared samples were characterized by SEM, FTIR, NMR, TGA, DSC and rheology.
",
  address="CEITEC",
  chapter="115916",
  doi="10.1371/journal.pone.0100028",
  howpublished="online",
  institution="CEITEC",
  year="2015",
  month="september",
  pages="132--132",
  publisher="CEITEC",
  type="abstract"
}