Detail publikace

Novel hydrogels based on natural polysaccharide Gum Karaya for soft tissue regeneration

POŠTULKOVÁ, H. NEDOMOVÁ, E. VOJTOVÁ, L. JANČÁŘ, J.

Originální název

Novel hydrogels based on natural polysaccharide Gum Karaya for soft tissue regeneration

Anglický název

Novel hydrogels based on natural polysaccharide Gum Karaya for soft tissue regeneration

Jazyk

en

Originální abstrakt

Natural polysaccharides are biodegradable, freely available, relatively cheap and nontoxic materials. They are widely used in food and pharmaceutical industry. Moreover, polysaccharide based hydrogels are promising for use in medicine. They provide moist environment which stimulates faster wound healing. Hydrogels can be utilized as wound dressing for soft tissue regeneration (e.g. skin burns or ulcers). Gum Karaya (GK) is a natural polysaccharide obtained from Sterculia urens tree. GK is anionic polysaccharide containing β-D-galactose, L-rhamnose, β-D-glucuronic acid and Dgalacturonic acid. Natural GK is partially acetylated high molecular weight polymer (Mw ≈ 9 mil Da) insoluble in water. On the other hand, GK is biodegradable and cheap having high swelling and retention capacity, high viscosity and inherent antimicrobial activity. Therefore, GK has good potential to be utilized in medicine. [1, 2] The objective of this study is preparation a soluble sample of GK by alkali treatment followed by designing new procedure for GK hydrogel preparation meeting properties of wound healing coverings. Prepared samples were, characterized by SEM, FTIR, NMR, TGA, DSC and rheological evaluated.

Anglický abstrakt

Natural polysaccharides are biodegradable, freely available, relatively cheap and nontoxic materials. They are widely used in food and pharmaceutical industry. Moreover, polysaccharide based hydrogels are promising for use in medicine. They provide moist environment which stimulates faster wound healing. Hydrogels can be utilized as wound dressing for soft tissue regeneration (e.g. skin burns or ulcers). Gum Karaya (GK) is a natural polysaccharide obtained from Sterculia urens tree. GK is anionic polysaccharide containing β-D-galactose, L-rhamnose, β-D-glucuronic acid and Dgalacturonic acid. Natural GK is partially acetylated high molecular weight polymer (Mw ≈ 9 mil Da) insoluble in water. On the other hand, GK is biodegradable and cheap having high swelling and retention capacity, high viscosity and inherent antimicrobial activity. Therefore, GK has good potential to be utilized in medicine. [1, 2] The objective of this study is preparation a soluble sample of GK by alkali treatment followed by designing new procedure for GK hydrogel preparation meeting properties of wound healing coverings. Prepared samples were, characterized by SEM, FTIR, NMR, TGA, DSC and rheological evaluated.

Dokumenty

BibTex


@misc{BUT115796,
  author="Hana {Poštulková} and Eva {Nedomová} and Lucy {Vojtová} and Josef {Jančář}",
  title="Novel hydrogels based on natural polysaccharide Gum Karaya for soft tissue regeneration",
  annote="Natural polysaccharides are biodegradable, freely available, relatively cheap and nontoxic materials. They are widely used in food and pharmaceutical industry. Moreover, polysaccharide based hydrogels are promising for use in medicine. They provide moist environment which stimulates faster wound healing. Hydrogels can be utilized as wound dressing for soft tissue regeneration (e.g. skin burns or ulcers).
Gum Karaya (GK) is a natural polysaccharide obtained from Sterculia urens tree. GK is anionic polysaccharide containing β-D-galactose, L-rhamnose, β-D-glucuronic acid and Dgalacturonic acid. Natural GK is partially acetylated high molecular weight polymer (Mw ≈ 9 mil Da) insoluble in water. On the other hand, GK is biodegradable and cheap having high swelling and retention capacity, high viscosity and inherent antimicrobial activity. Therefore, GK has good potential to be utilized in medicine. [1, 2]
The objective of this study is preparation a soluble sample of GK by alkali treatment followed by designing new procedure for GK hydrogel preparation meeting properties of wound healing coverings. Prepared samples were, characterized by SEM, FTIR, NMR, TGA, DSC and rheological evaluated.",
  address="Masaryk University",
  booktitle="CEITEC PHD RETREAT",
  chapter="115796",
  howpublished="print",
  institution="Masaryk University",
  year="2015",
  month="april",
  pages="112--112",
  publisher="Masaryk University",
  type="abstract"
}