Detail publikačního výsledku

Beyond the Critical Micelle Concentration: Formulation of the Bilayer Vesicles in PLGA–PEG–PLGA Copolymers Targeting for Drug Delivery

KOTOUČEK, J.; CHAMRADOVÁ, I.; KADLECOVÁ, Z.; TUŠLOVÁ, K.; HLINÁKOVÁ, K.; PETRUŠ, J.; SAHUĽ, M.; MICHLOVSKÁ, L.; ŽÍDEK, J.; VOJTOVÁ, L.

Originální název

Beyond the Critical Micelle Concentration: Formulation of the Bilayer Vesicles in PLGA–PEG–PLGA Copolymers Targeting for Drug Delivery

Anglický název

Beyond the Critical Micelle Concentration: Formulation of the Bilayer Vesicles in PLGA–PEG–PLGA Copolymers Targeting for Drug Delivery

Druh

Abstrakt

Originální abstrakt

Poly(D,L-lactic acid-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(D,L-lactic acid-co-glycolic acid) (PLGA–PEG–PLGA) is amphiphilic triblock copolymer able to form an organized nanostructures when exceeding the critical micelle concentration (CMC). We hypothesize that PLGA–PEG–PLGA can form polymer bilayers (i.e., polymersomes) even below the CMC, challenging the traditional paradigm. The possibility of these bilayer vesicles bears similarities to lipid-based membranes. Understanding whether these nanoscale assemblies under sub-CMC conditions is crucial for drug delivery and biomedical applications at low polymer concentrations.

Anglický abstrakt

Poly(D,L-lactic acid-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(D,L-lactic acid-co-glycolic acid) (PLGA–PEG–PLGA) is amphiphilic triblock copolymer able to form an organized nanostructures when exceeding the critical micelle concentration (CMC). We hypothesize that PLGA–PEG–PLGA can form polymer bilayers (i.e., polymersomes) even below the CMC, challenging the traditional paradigm. The possibility of these bilayer vesicles bears similarities to lipid-based membranes. Understanding whether these nanoscale assemblies under sub-CMC conditions is crucial for drug delivery and biomedical applications at low polymer concentrations.

Klíčová slova

Thermosensitive degradable copolymer, critical micelle concentration

Klíčová slova v angličtině

Thermosensitive degradable copolymer, critical micelle concentration

Autoři

KOTOUČEK, J.; CHAMRADOVÁ, I.; KADLECOVÁ, Z.; TUŠLOVÁ, K.; HLINÁKOVÁ, K.; PETRUŠ, J.; SAHUĽ, M.; MICHLOVSKÁ, L.; ŽÍDEK, J.; VOJTOVÁ, L.

Vydáno

06.05.2025

Místo

Vanajanlinna, Hämeenlinna, Finland

Strany od

22

Strany do

22

Strany počet

64

URL

chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://events.tuni.fi/app/uploads/2025/05/094c07de-scsb-2025-abstracts-poster-presentations.pdf

BibTex

@misc{BUT200666,
  author="{} and Jan {Kotouček} and Ivana {Chamradová} and Zuzana {Kadlecová} and Klára {Tušlová} and  {} and Kristýna {Hlináková} and Josef {Petruš} and Martin {Sahuľ} and Lenka {Michlovská} and Jan {Žídek} and Lucy {Vojtová}",
  title="Beyond the Critical Micelle Concentration: Formulation of the Bilayer Vesicles in PLGA–PEG–PLGA Copolymers Targeting for Drug Delivery",
  year="2025",
  pages="22--22",
  address="Vanajanlinna, Hämeenlinna, Finland",
  url="chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://events.tuni.fi/app/uploads/2025/05/094c07de-scsb-2025-abstracts-poster-presentations.pdf",
  note="Abstract"
}