Role of gemini surfactants with biodegradable spacer as efficient capping agents of silver nanoparticles

Role of gemini surfactants with biodegradable spacer as efficient capping agents of silver nanoparticles

Článek WoS

Since the last decade, silver nanoparticles (AgNPs) continue to attract interest of both academia and industry due to their peculiar physical, chemical, and optical properties. In the field of pharmaceutical applications, they are efficient carriers in the processes of controlled drug release, improve the drug's bioavailability, act as efficient antimicrobial agents and provide other biological functions conveyed at the nanometric scale. The known issue hampering further development of applications of AgNPs is their instability in aqueous environment. The present study utilizes two series of cationic bisammonium gemini surfactants with two dodecyl chains and a biodegradable spacer containing two amide or ester groups for the stabilization of AgNPs. The presence of nanosilver in the dispersions was confirmed by UV-VIS plasmon resonance spectra. Stability of AgNPs was characterized by zeta potential measurements proving that amide and ester gemini surfactant series are able to effectively stabilize AgNPs. The particles size analysis utilizing dynamic light scattering and scanning electron microscopy showed that AgNPs stabilized with flexible ester-based gemini surfactants have their size smaller than those capped with amide-containing gemini surfactants. Antimicrobial and anti-inflammatory activity determination as well as cytotoxicity experiments with gemini surfactant stabilized AgNPs showed a complex dependence of biological activity of AgNPs on the molecular structure of stabilizing agents.

Since the last decade, silver nanoparticles (AgNPs) continue to attract interest of both academia and industry due to their peculiar physical, chemical, and optical properties. In the field of pharmaceutical applications, they are efficient carriers in the processes of controlled drug release, improve the drug's bioavailability, act as efficient antimicrobial agents and provide other biological functions conveyed at the nanometric scale. The known issue hampering further development of applications of AgNPs is their instability in aqueous environment. The present study utilizes two series of cationic bisammonium gemini surfactants with two dodecyl chains and a biodegradable spacer containing two amide or ester groups for the stabilization of AgNPs. The presence of nanosilver in the dispersions was confirmed by UV-VIS plasmon resonance spectra. Stability of AgNPs was characterized by zeta potential measurements proving that amide and ester gemini surfactant series are able to effectively stabilize AgNPs. The particles size analysis utilizing dynamic light scattering and scanning electron microscopy showed that AgNPs stabilized with flexible ester-based gemini surfactants have their size smaller than those capped with amide-containing gemini surfactants. Antimicrobial and anti-inflammatory activity determination as well as cytotoxicity experiments with gemini surfactant stabilized AgNPs showed a complex dependence of biological activity of AgNPs on the molecular structure of stabilizing agents.

Silver nanoparticle; Biodegradable spacer; Gemini surfactant; Amide group; Ester group; Hydrodynamic diameter

Silver nanoparticle; Biodegradable spacer; Gemini surfactant; Amide group; Ester group; Hydrodynamic diameter

PISÁRČIK, M.; ZÁTEKOVÁ, M.; OLÁHOVÁ, K.; LUKÁČ, M.; JAMPÍLEK, J.; BILKOVÁ, A.; BILKA, F.; DEVÍNSKY, F.; BŘEZINA, M.; BREZÁNI, V.; HOŠEK, J.; OPRAVIL, T.

2026

07.09.2024

ELSEVIER

Journal of drug delivery science and technology

101

1

Nizozemsko

12

https://doi.org/10.1016/j.jddst.2024.106162