Detail publikace

Ex-vivo biomechanical testing of pig femur diaphysis B type fracture fixed by novel biodegradable bone glue

KRTIČKA, M. MICHLOVSKÁ, L. NEKUDA, V. POLÁČEK, P. VALOVÁ, K. ŽÍDEK, J. KAISER, J. ZIKMUND, T. VOJTOVÁ, L.

Originální název

Ex-vivo biomechanical testing of pig femur diaphysis B type fracture fixed by novel biodegradable bone glue

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

This study aimed to answer the question whether our newly developed injectable biodegradable “self-setting” polymer composite as a bone adhesive is a good “bone-glue” candidate to efficiently fix comminuted fractures of pig femoral bone used as an ex-vivo experimental model. Mechanical properties of the adhesive prepared from α-tricalcium phosphate (TCP) powder and thermosensitive copolymer were optimized by selecting the appropriate composition with adhesion enhancers based on dopamine and sodium iodinate. Setting time and injectability were controlled by rheology. Ex-vivo experiments of fixed pig bones were provided in terms of either the three-point bending test of bending wedge type fractured pig femurs (with LCP) or the axial compression test of 45° oblique fractured femurs (without LCP). Fractured bones glued with optimized adhesive before and after bending tests were imaged by X-ray microtomography (μCT).

Klíčová slova

biomechanics, adhesive, biodegradable polymer, bone, ex-vivo, fracture, microtomography, rheology, tixotropy

Autoři

KRTIČKA, M.; MICHLOVSKÁ, L.; NEKUDA, V.; POLÁČEK, P.; VALOVÁ, K.; ŽÍDEK, J.; KAISER, J.; ZIKMUND, T.; VOJTOVÁ, L.

Vydáno

1. 3. 2021

Nakladatel

Elsevier Ltd

Místo

RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS

ISSN

1751-6161

Periodikum

Journal of the mechanical behavior of biomedical materials

Číslo

115

Stát

Nizozemsko

Strany od

1

Strany do

8

Strany počet

8

URL

https://www-sciencedirect-com.ezproxy.lib.vutbr.cz/science/article/pii/S1751616120307888

BibTex

@article{BUT170217,
  author="Milan {Krtička} and Lenka {Michlovská} and Vladimír {Nekuda} and Petr {Poláček} and Kristýna {Hlináková} and Jan {Žídek} and Jozef {Kaiser} and Tomáš {Zikmund} and Lucy {Vojtová}",
  title="Ex-vivo biomechanical testing of pig femur diaphysis B type fracture fixed by novel biodegradable bone glue",
  journal="Journal of the mechanical behavior of biomedical materials",
  year="2021",
  number="115",
  pages="1--8",
  doi="10.1016/j.jmbbm.2020.104249",
  issn="1751-6161",
  url="https://www-sciencedirect-com.ezproxy.lib.vutbr.cz/science/article/pii/S1751616120307888"
}