Biopolymers Properties and Applications
FCH-MAA_BPAAcad. year: 2018/2019
Introduction about biomaterial. Biopolymers (extraction from different sources, characterization. Relation between extraction process and chemical/physical properties of biopolymers. Chemical modification of biopolymers to obtain different properties/different shapes of materials. The applications of the biopolymers in different areas (medical, environmental, textile, pharmaceutics and tissue engineering applications).
Offered to foreign students
Of all faculties
Learning outcomes of the course unit
Students will improve their knowledge about the biopolymers: Extraction from different sources, characterizations and chemical modifications of biopolymers. Medical and environmental applications of biomaterials.
Basic knowledge of organic technology.
Recommended optional programme components
Recommended or required reading
Farzana Parveen, Recent Advances in Biopolymers, Elsevier, 2016, 281 (EN)
Vijay Kumar Thakur, Amar Singh Singha, Surface Modification of Biopolymers, Wiley, 2015, 448 (EN)
Alen Walton (Auth.), biopolymers, Elsevier Science,1973,610 (EN)
Gerald O. Aspinall (Auth.), Polysaccharides, Pergamon Press, 1970,242 (EN)
Jean-Michel Mérillon (eds.), Polysaccharides: Bioactivity and Biotechnology, Springer International Publishing,2015,2241 Springer International Publishing,2015,2241 • Jean-Michel Mérillon (eds.), Polysaccharides: Bioactivity and Biotechnology, Springer International Publishing,2015,2241 (EN)
Robert H. Marchessault, François Ravenelle, and Xiao Xia Zhu (Eds.), ACS Symposium Volume 934; Polysaccharides for Drug Delivery and Pharmaceutical Applications, American Chemical Society,2006,354 (EN)
Planned learning activities and teaching methods
90 % face-to-face, 10 % distance learning
Assesment methods and criteria linked to learning outcomes
Written test /oral examination/activity participation in lectures (70/20/10)
Language of instruction
Lecture 1: Introduction about biopolymers such as cellulose/oxycellulose, starch, chitin, dextrin, chitosan, hyaluronic acid, alginate, chitin-glucan complex, pectin, etc.... and their classifications depend on the following parameters.
Depend on functionality (amino, carboxylic, hydroxyl, thiol, acetamide, etc….).
Classification depend on structure (mono, di, branched, etc….).
Depend applications such as biomedical and environmental purposes.
Lecture 2: Different extraction process of biopolymers:
Chemically (using different chemical treatment),
Enzymatically (using different enzymes as glucanase, cellulose, hyaluronidase),
Mechanically (thermal/mechanical treatment).
Lecture 3: Characterization of biopolymers by different techniques and confirmation the structure by measure:
Degree of polymerization, degree of deaceytlayion/acetylation, carboxylation, thiolation, oxidation,
Molecular weight calculation,
Degree of substitution on the linear or branched chains.
Lecture 4: Chemical modifications of by biopolymers:
Amidation, esterification, graft copolymerization,
Quaternization of biopolymers, alkylation, oxidation,
Photo/chemical/physical cross-linking of the surface of biopolymers like chitin, chitosan, hyaluronic acids, alginate, cellulose, chitosan-glucan complex, silk fibroin, carrageenan to generate new different chemical/physical properties
Lecture 5: Preparation of different forms of biopolymers like:
Membranes, films, fibers/ fabrics, hydrogel, powders,
3D structure using freeze thawing, freeze-drying, precipitation,
Casting, wet/electrospinning techniques.
Lecture 6: The medical uses of biopolymers as:
Healing/dressing wound, cell carrier,
Antibacterial agents and for bone/cartilage regenerations,
Environmental application epically for waste water treatments and removing all hazard metals/organic substance.
Lecture 7: Uses of biomaterial (native/modified) in preparation/synthetization of:
Different metal/metal oxide nanoparticles as reducing/ stabilizing/capping agents such as,
Gold nanoparticles and zinc oxide nanoparticles,
Titanium oxide nanoparticles and nanohydroxy apatite and their applications.
Lecture 8: The mechanisms of interactions between metal/metal oxide nanoparticles and biomaterials (native/modified):
Stabilizing the metal/metal oxide nanoparticles
reduction of metal/metal oxide nanoparticles using biopolymers such as cellulose/oxy-cellulose, starch, chitin, dextrin, chitosan, hyaluronic acid, alginate, chitin-glucan complex, pectin
Prevent the aggregation and agglomeration of metal nanoparticles and,
Preparation of nanocomposite materials.
Lecture 9: The environmental applications of biopolymers:
Uses of biopolymers such as chitin, chitosan, cyclodextrin, cellulose and their derivatives on metals and organic material removal,
Uses of biopolymer nanocomposite on wastewater treatments,
biopolymer smart coating and sensors
Lecture 10: General overview of biopolymers and implantation process (internal and external applications of biopolymers).
Biodegradable biopolymers based scaffold for bone tissue engineering,
Biodegradable polymers based scaffold for cartilage tissue engineering,
Biodegradable polymers based sheets for skin tissue regeneration.
Lecture 11: The chemical modification between biomaterials (native/modified) with;
Synthetic polymers (poly-carbolactone, polyvinyl alcohol, polyethylene oxide….),
Proteins (collagen, peptides) and their applications.
The main aim of the course is to improve the background of the students how to use the natural sources (animal/non animal) in order to obtain biopolymers and usage in different sectors of our life (medicine, agriculture, pharmaceutics, textile, drug delivery, etc……).
Classification of course in study plans
- Programme DPCP_CHM_4 Doctoral
branch DPCO_CHM_4 , 1. year of study, winter semester, 0 credits, elective
- Programme DPAP_CHM_4 Doctoral
branch DPAO_CHM_4 , 1. year of study, winter semester, 0 credits, elective
- Programme DKCP_CHM_4 Doctoral
branch DKCO_CHM_4 , 1. year of study, winter semester, 0 credits, elective
- Programme DKAP_CHM_4 Doctoral
branch DKAO_CHM_4 , 1. year of study, winter semester, 0 credits, elective
- Programme AKREDITACE Doctoral, 1. year of study, winter semester, 0 credits, elective
- Programme DPCP_MCH_4 Doctoral
branch DPCO_MCH , 1. year of study, winter semester, 0 credits, elective
- Programme DKCP_MCH_4 Doctoral
branch DKCO_MCH , 1. year of study, winter semester, 0 credits, elective
- Programme NPCP_CHM Master's
- Programme NKCP_CHM Master's
- Programme NPCP_CHM_INT Master's
- Programme NPCP_CHM Master's
- Programme NKCP_CHM Master's
Type of course unit
26 hours, optionally
Teacher / Lecturer