Publication detail

Square wave voltammetry as a tool for study of ellipticine-DNA interaction

MASAŘÍK,M. HÚSKA,D. ADAM,V. HUBALEK,J. PROVAZNÍK, I. TRNKOVÁ,L. ECKSCHLAGER,T. STIBOROVÁ,M. KIZEK,R.

Original Title

Square wave voltammetry as a tool for study of ellipticine-DNA interaction

Type

abstract

Language

English

Original Abstract

Ellipticine and its derivates belong to prototype compounds acting predominantly by DNA-damaging mechanisms and serving as cytostaic agents. The aim of this work was to study the intercalation of the ellipticine into DNA. For this purpose we utilized adsorptive transfer stripping technique (AdTS) coupled with square wave voltammetry (SWV). Primarily, we investigated the influence of ellipticine on genomic DNA electrochemical signals. Decrease in redox signal of cytosine/adenine (at -1.4 V) was observed as a result of ellipticine intercalation into DNA. The decrease was proportional to increasing concentration of ellipticine.

Keywords

Ellipticine, DNA

Authors

MASAŘÍK,M.; HÚSKA,D.; ADAM,V.; HUBALEK,J.; PROVAZNÍK, I.; TRNKOVÁ,L.; ECKSCHLAGER,T.; STIBOROVÁ,M.; KIZEK,R.

Released

1. 1. 2010

Publisher

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

ISBN

1107-3756

Periodical

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Year of study

26

Number

1

State

United States of America

Pages from

S46

Pages to

S46

Pages count

1