Publication detail

A Comparative Tool for the Validity of Rate Kinetics in Ion Channels by Onsager Reciprocity Theorem

OZER, M. PROVAZNÍK, I.

Original Title

A Comparative Tool for the Validity of Rate Kinetics in Ion Channels by Onsager Reciprocity Theorem

Type

journal article - other

Language

English

Original Abstract

The precise form of the rate constant functions of ion channels is very crucial for reproducing the electrophysiological behavior. Therefore, how well they account for experimental data plays an important role in the behavior of the model. In this study, we derive kinetic coefficients of activation and inactivation gates in ion channels by Onsager reciprocity theorem for an ensemble of gating particles, and propose that the obtained kinetic coefficients can be used as a comparative tool for the empirical validity of fitted rate constant functions to experimental data. We also illustrate its applicability based on the activation and inactivation kinetics of T-type calcium channel in thalamic relay neurons. We show that the shape of the steady-state curve by itself seems to be a poor indicator of the functional form of the rate functions, but the time constant curves reflect considerable variation depending on the particular form of the rate functions, and that the kinetic coefficients related to the time constants provide a powerful tool to determine the empirical validity of the fitted rate constants.

Keywords

Kinetic coefficient; Ion channel; Rate kinetics; Onsager reciprocity theorem

Authors

OZER, M.; PROVAZNÍK, I.

RIV year

2004

Released

1. 10. 2004

Publisher

Elsevier

ISBN

0022-5193

Periodical

Journal of Theoretical Biology

Year of study

233

Number

2

State

United States of America

Pages from

237

Pages to

243

Pages count

7

BibTex

@article{BUT42154,
  author="Mahmut {Ozer} and Valentine {Provazník}",
  title="A Comparative Tool for the Validity of Rate Kinetics in Ion Channels by Onsager Reciprocity Theorem",
  journal="Journal of Theoretical Biology",
  year="2004",
  volume="233",
  number="2",
  pages="7",
  issn="0022-5193"
}