3D-printed transmembrane glycoprotein cancer biomarker aptasensor

journal article in Web of Science

English

A B S T R A C T Point-of-care, easy to manufacture, and low cost detection of cancer biomarkers is crucial for fighting the early stage disease. 3D printing allows delocalized printing at remote locations with updates/upgrades available globally via electronic files. Mucin 1 (MUC1) is a protein that is overexpressed in a number of epithelial cancers and is a key factor in advancement of the disease. Here we show the simple point of-care 3D printing fabrication of a MUC1 aptasensor using a nanocarbon/polymer filament. Efficacy of the 3D-printed aptasensor is demonstrated by monitoring the expression and release of MUC1 in breast cancer cell cultures. Such a simple, low cost, and easy to locally fabricate cancer biosensor will have a large impact on the field of cancer diagnostics. (c) 2021 Elsevier Ltd. All rights reserved.

Additive manufacturing; Aptamer; Breast cancer cells; Biomarker; Sensor

CREVILLEN, A.; MAYORGA-MARTINEZ, C.; ZELENKA, J.; RIMPELOVÁ, S.; RUML, T.; PUMERA, M.

1. 9. 2021

ELSEVIER

AMSTERDAM

2352-9407

Applied Materials Today

24

1

Kingdom of the Netherlands

101153-1

101153-5

5

https://www.sciencedirect.com/science/article/pii/S2352940721002171?via%3Dihub