Publication detail

Silicane Derivative Increases Doxorubicin Efficacy in an Ovarian Carcinoma Mouse Model: Fighting Drug Resistance

FOJTŮ, M. BALVAN, J. VIČAR, T. POLANSKÁ, H. PELTANOVÁ, B. MATĚJKOVÁ, S. RAUDENSKÁ, M. ŠTURALA, J. MAYORGA BURREZO, P. MASAŘÍK, M. PUMERA, M.

Original Title

Silicane Derivative Increases Doxorubicin Efficacy in an Ovarian Carcinoma Mouse Model: Fighting Drug Resistance

Type

journal article in Web of Science

Language

English

Original Abstract

The development of cancer resistance continues to represent a bottleneck of cancer therapy. It is one of the leading factors preventing drugs to exhibit their full therapeutic potential. Consequently, it reduces the efficacy of anticancer therapy and causes the survival rate of therapy-resistant patients to be far from satisfactory. Here, an emerging strategy for overcoming drug resistance is proposed employing a novel two-dimensional (2D) nanomaterial polysiloxane (PSX). We have reported on the synthesis of PSX nanosheets (PSX NSs) and proved that they have favorable properties for biomedical applications. PSX NSs evinced unprecedented cytocompatibility up to the concentration of 300 mu g/mL, while inducing very low level of red blood cell hemolysis and were found to be highly effective for anticancer drug binding. PSX NSs enhanced the efficacy of the anticancer drug doxorubicin (DOX) by around 27.8-43.4% on average and, interestingly, were found to be especially effective in the therapy of drug-resistant tumors, improving the effectiveness of up to 52%. Fluorescence microscopy revealed improved retention of DOX within the drug-resistant cells when bound on PSX NSs. DOX bound on the surface of PSX NSs, i.e., PSX@DOX, improved, in general, the DOX cytotoxicity in vitro. More importantly, PSX@DOX reduced the growth of DOX-resistant tumors in vivo with 3.5 times better average efficiency than the free drug. Altogether, this paper represents an introduction of a new 2D nanomaterial derived from silicane and pioneers its biomedical application. As advances in the field of material synthesis are rapidly progressing, novel 2D nanomaterials with improved properties are being synthesized and await thorough exploration. Our findings further provide a better understanding of the mechanisms involved in the cancer resistance and can promote the development of a precise cancer therapy.

Keywords

2D nanomaterials; silicene; polysiloxane; nanosheets; targeted drug delivery; doxorubicin; ovarian cancer; drug resistance

Authors

FOJTŮ, M.; BALVAN, J.; VIČAR, T.; POLANSKÁ, H.; PELTANOVÁ, B.; MATĚJKOVÁ, S.; RAUDENSKÁ, M.; ŠTURALA, J.; MAYORGA BURREZO, P.; MASAŘÍK, M.; PUMERA, M.

Released

14. 7. 2021

Publisher

AMER CHEMICAL SOC

Location

WASHINGTON

ISBN

1944-8252

Periodical

ACS applied materials & interfaces

Year of study

13

Number

27

State

United States of America

Pages from

31355

Pages to

31370

Pages count

16

URL

BibTex

@article{BUT172538,
  author="Michaela {Fojtů} and Jan {Balvan} and Tomáš {Vičar} and Hana {Polanská} and Barbora {Peltanová} and Stanislava {Matějková} and Martina {Raudenská} and Jiří {Šturala} and Paula {Mayorga Burrezo} and Michal {Masařík} and Martin {Pumera}",
  title="Silicane Derivative Increases Doxorubicin Efficacy in an Ovarian Carcinoma Mouse Model: Fighting Drug Resistance",
  journal="ACS applied materials & interfaces",
  year="2021",
  volume="13",
  number="27",
  pages="31355--31370",
  doi="10.1021/acsami.0c20458",
  issn="1944-8252",
  url="https://pubs.acs.org/doi/10.1021/acsami.0c20458"
}