Publication detail

Cancer Cells Microsurgery via Asymmetric Bent Surface Au/Ag/Ni Microrobotic Scalpels Through a Transversal Rotating Magnetic Field

VYSKOČIL, J. MAYORGA-MARTINEZ, C. JABLONSKÁ, E. NOVOTNÝ, F. RUML, T. PUMERA, M.

Original Title

Cancer Cells Microsurgery via Asymmetric Bent Surface Au/Ag/Ni Microrobotic Scalpels Through a Transversal Rotating Magnetic Field

Type

journal article in Web of Science

Language

English

Original Abstract

The actuation of micro/nanomachines by means of a magnetic field is a promising fuel-free way to transport cargo in microscale dimensions. This type of movement has been extensively studied for a variety of micro/nanomachine designs, and a special magnetic field configuration results in a near-surface walking. We developed "walking" micromachines which transversally move in a magnetic field, and we used them as microrobotic scalpels to enter and exit an individual cancer cell and cut a small cellular fragment. In these microscalpels, the center of mass lies approximately in the middle of their length. The microrobotic scalpels show good propulsion efficiency and high step-out frequencies of the magnetic field. Au/Ag/Ni microrobotic scalpels controlled by a transversal rotating magnetic field can enter the cytoplasm of cancer cells and also are able to remove a piece of the cytosol while leaving the cytoplasmic membrane intact in a microsurgery-like manner. We believe that this concept can be further developed for potential biological or medical applications.

Keywords

micromotors; self-propulsion; surface walker; magnetic field; cancer treatment

Authors

VYSKOČIL, J.; MAYORGA-MARTINEZ, C.; JABLONSKÁ, E.; NOVOTNÝ, F.; RUML, T.; PUMERA, M.

Released

28. 7. 2020

Publisher

AMER CHEMICAL SOC

Location

WASHINGTON

ISBN

1936-0851

Periodical

ACS Nano

Year of study

14

Number

7

State

United States of America

Pages from

8247

Pages to

8256

Pages count

10

URL

https://pubs.acs.org/doi/abs/10.1021/acsnano.0c01705

BibTex

@article{BUT166330,
  author="Jan {Vyskočil} and Carmen C. {Mayorga-Martinez} and Eva {Jablonská} and Filip {Novotný} and Tomáš {Ruml} and Martin {Pumera}",
  title="Cancer Cells Microsurgery via Asymmetric Bent Surface Au/Ag/Ni Microrobotic Scalpels Through a Transversal Rotating Magnetic Field",
  journal="ACS Nano",
  year="2020",
  volume="14",
  number="7",
  pages="8247--8256",
  doi="10.1021/acsnano.0c01705",
  issn="1936-0851",
  url="https://pubs.acs.org/doi/abs/10.1021/acsnano.0c01705"
}