Publication detail

FDM 3D Printed Composites for Bone Tissue Engineering Based on Plasticized Poly(3-hydroxybutyrate)/poly(d,l-lactide) Blends

MELČOVÁ, V. CHALOUPKOVÁ, K. MENČÍK, P. KONTÁROVÁ, S. RAMPICHOVÁ, M. HEDVIČÁKOVÁ, V. SOVKOVÁ, V. PŘIKRYL, R. VOJTOVÁ, L.

Original Title

FDM 3D Printed Composites for Bone Tissue Engineering Based on Plasticized Poly(3-hydroxybutyrate)/poly(d,l-lactide) Blends

Type

journal article in Web of Science

Language

English

Original Abstract

Tissue engineering is a current trend in the regenerative medicine putting pressure on scientists to develop highly functional materials and methods for scaffolds’ preparation. In this paper, the calibrated filaments for Fused Deposition Modeling (FDM) based on plasticized poly(3-hydroxybutyrate)/poly(d,l-lactide) 70/30 blend modified with tricalcium phosphate bioceramics were prepared. Two different plasticizers, Citroflex (n-Butyryl tri-n-hexyl citrate) and Syncroflex (oligomeric adipate ester), both used in the amount of 12 wt%, were compared. The printing parameters for these materials were optimized and the printability was evaluated by recently published warping test. The samples were studied with respect to their thermal and mechanical properties, followed by biological in vitro tests including proliferation, viability, and osteogenic differentiation of human mesenchymal stem cells. According to the results from differential scanning calorimetry and tensile measurements, the Citroflex-based plasticizer showed very good softening effect at the expense of worse printability and unsatisfactory performance during biological testing. On the other hand, the samples with Syncroflex demonstrated lower warping tendency compared to commercial polylactide filament with the warping coefficient one third lower. Moreover, the Syncroflex-based samples exhibited the non-cytotoxicity and promising biocompatibility.

Keywords

additive manufacturing; fused deposition modeling; poly(3-hydroxybutyrate); polylactide; tricalcium phosphate; regenerative medicine; tissue engineering; bone scaffolds

Authors

MELČOVÁ, V.; CHALOUPKOVÁ, K.; MENČÍK, P.; KONTÁROVÁ, S.; RAMPICHOVÁ, M.; HEDVIČÁKOVÁ, V.; SOVKOVÁ, V.; PŘIKRYL, R.; VOJTOVÁ, L.

Released

27. 11. 2020

Publisher

MDPI

Location

Basel

ISBN

2073-4360

Periodical

Polymers

Year of study

12

Number

12

State

Swiss Confederation

Pages from

1

Pages to

19

Pages count

19

URL

Full text in the Digital Library

BibTex

@article{BUT166290,
  author="Veronika {Melčová} and Kateřina {Chaloupková} and Přemysl {Menčík} and Soňa {Kontárová} and Michaela {Rampichová} and Věra {Hedvičáková} and Věra {Sovková} and Radek {Přikryl} and Lucy {Vojtová}",
  title="FDM 3D Printed Composites for Bone Tissue Engineering Based on Plasticized Poly(3-hydroxybutyrate)/poly(d,l-lactide) Blends",
  journal="Polymers",
  year="2020",
  volume="12",
  number="12",
  pages="1--19",
  doi="10.3390/polym12122806",
  issn="2073-4360",
  url="https://www.mdpi.com/2073-4360/12/12/2806"
}

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