Publication detail

Self-Propelled Autonomous Mg/Pt Janus Micromotor Interaction with Human Cells

KONG, L. ROSLI, N. CHIA, H. GUAN, J. PUMERA, M.

Original Title

Self-Propelled Autonomous Mg/Pt Janus Micromotor Interaction with Human Cells

Type

journal article in Web of Science

Language

English

Original Abstract

Magnesium (Mg)-based micromotors have attracted considerable attention as they are capable of moving in water and human blood plasma without external fuels. It has also been demonstrated that they have potential for drug delivery in mouse stomach. However, their biocompatibility and cytotoxicity to human cells have yet to be studied. Therefore, we performed cytotoxicity study of Mg/Pt Janus micromotors with human lung carcinoma epithelial cells (A549), human breast cancer cells (MCF-7), human embryonic kidney cells (HEK-293), human liver carcinoma cells (HepG2) and human cervical cancer cells (HeLa). The highest concentration of micromotors tested, 200 mu g mL(-1), drastically induced a high toxic effect on the cells and reduced the cell viability to below 60%. This shows while Pt/Au nanomachines were found to be safe previously, this is not the case of the Mg/Pt micromachines.

Keywords

Cytotoxicity; Micromotors; Human cells

Authors

KONG, L.; ROSLI, N.; CHIA, H.; GUAN, J.; PUMERA, M.

Released

1. 10. 2019

Publisher

CHEMICAL SOC JAPAN

Location

TOKYO

ISBN

0009-2673

Periodical

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

Year of study

92

Number

10

State

Japan

Pages from

1754

Pages to

1758

Pages count

5

URL

https://www.journal.csj.jp/doi/10.1246/bcsj.20190104

BibTex

@article{BUT163619,
  author="Lei {Kong} and Nur Farhanah {Rosli} and Hui Ling {Chia} and Jianguo {Guan} and Martin {Pumera}",
  title="Self-Propelled Autonomous Mg/Pt Janus Micromotor Interaction with Human Cells",
  journal="BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN",
  year="2019",
  volume="92",
  number="10",
  pages="1754--1758",
  doi="10.1246/bcsj.20190104",
  issn="0009-2673",
  url="https://www.journal.csj.jp/doi/10.1246/bcsj.20190104"
}