Publication detail

Micromotors as "Motherships": A Concept for the Transport, Delivery, and Enzymatic Release of Molecular Cargo via Nanoparticles

KROUPA, T. HERMANOVÁ, S. MAYORGA-MARTINEZ, C. NOVOTNÝ, F. SOFER, Z. PUMERA, M.

Original Title

Micromotors as "Motherships": A Concept for the Transport, Delivery, and Enzymatic Release of Molecular Cargo via Nanoparticles

Type

journal article in Web of Science

Language

English

Original Abstract

Nano/micromotors based on biodegradable and biocompatible polymers represent a progressively developing group of self-propelled artificial devices capable of delivering biologically active compounds to target sites. The majority of these machines are micron sized, and biologically active compounds are simply attached to their surface. Micron-sized devices cannot enter cells, but they provide rapid velocity, which scales down with the size of the device; nanosized devices can enter cells, but their velocity is negligible. An advanced hierarchical design of the micro/nanodevices is an important tool in the development of functional biocompatible transport systems and their implementation in real in vivo applications. In this work, we demonstrate a "mothership" concept, whereby self-propelled microrobots transport smaller cargo-carrying nanorobots that are released by enzymatic degradation.

Keywords

JANUS MICROMOTORS; DRIVEN; MICROFISH; MOBILITY; SENSORS; IMPACT; MOTION

Authors

KROUPA, T.; HERMANOVÁ, S.; MAYORGA-MARTINEZ, C.; NOVOTNÝ, F.; SOFER, Z.; PUMERA, M.

Released

13. 8. 2019

ISBN

0743-7463

Periodical

Langmuir

Year of study

35

Number

32

State

United States of America

Pages from

10618

Pages to

10624

Pages count

7

URL

https://pubs.acs.org/doi/abs/10.1021/acs.langmuir.9b01192

BibTex

@article{BUT159810,
  author="Tomáš {Kroupa} and Soňa {Hermanová} and Carmen C. {Mayorga-Martinez} and Filip {Novotný} and Zdeněk {Sofer} and Martin {Pumera}",
  title="Micromotors as {"}Motherships{"}: A Concept for the Transport, Delivery, and Enzymatic Release of Molecular Cargo via Nanoparticles",
  journal="Langmuir",
  year="2019",
  volume="35",
  number="32",
  pages="10618--10624",
  doi="10.1021/acs.langmuir.9b01192",
  issn="0743-7463",
  url="https://pubs.acs.org/doi/abs/10.1021/acs.langmuir.9b01192"
}