Publication detail

Experimental and computational modelling of flow of fibres in human airways

LÍZAL, F. ELCNER, J. JEDELSKÝ, J. FARKAS, Á. MALÝ, M. PECH, O. MIŠÍK, O. JÍCHA, M.

Original Title

Experimental and computational modelling of flow of fibres in human airways

Type

abstract

Language

English

Original Abstract

The ability of fibres to align with the flow has been identified as a reason for higher penetration of fibres into the lungs compared to spherical particles by many studies. However, prediction of the fate of inhaled fibres by computational methods is complicated due to the necessary mathematical apparatus and the lack of experimental data for validation. It is common to apply coefficients accounting for the preferential orientation of the fibre flowing through the airways. A new experimental rig has been built to visualize the flow of micron-sized fibres and record the angles of their rotation upstream and downstream of a single bifurcation. The recorded angles are statistically analysed and improved coefficients of fibre orientation will be calculated. The experimental rig consists of a dielectrophoretic classifier of fibres, the model of human trachea and first bronchi, a breathing simulator and a high-speed camera with appropriate illumination. These experiments are supplemented with computational simulations and experimental measurement of deposition of fibres in a replica of human lungs comprising of the upper airways and first seven generations of tracheobronchial tree branching

Keywords

human airways, lung flow, fiber flow, fiber modelling, experimental modelling

Authors

LÍZAL, F.; ELCNER, J.; JEDELSKÝ, J.; FARKAS, Á.; MALÝ, M.; PECH, O.; MIŠÍK, O.; JÍCHA, M.

Released

1. 6. 2019

Publisher

MARY ANN LIEBERT, INC

Location

22nd Congress of International Society for Aerosols in Medicine e.V., Montreux, Switzerland

ISBN

1941-2711

Periodical

JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY

Year of study

32

Number

3

State

United States of America

Pages from

1

Pages to

1

Pages count

1

URL

https://www.liebertpub.com/doi/full/10.1089/jamp.2019.ab02.abstracts

BibTex

@misc{BUT157516,
  author="František {Lízal} and Jakub {Elcner} and Jan {Jedelský} and Árpád {Farkas} and Milan {Malý} and Ondřej {Pech} and Ondrej {Mišík} and Miroslav {Jícha}",
  title="Experimental and computational modelling of flow of fibres in human airways",
  year="2019",
  journal="JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY",
  volume="32",
  number="3",
  pages="1--1",
  publisher="MARY ANN LIEBERT, INC",
  address="22nd Congress of International Society for Aerosols in Medicine e.V., Montreux, Switzerland",
  issn="1941-2711",
  url="https://www.liebertpub.com/doi/full/10.1089/jamp.2019.ab02.abstracts",
  note="abstract"
}