Publication detail

Effect of Transmural Differences in Excitation-Contraction Delay and Contraction Velocity on Left Ventricle Isovolumic Contraction: A Simulation Study

VAVERKA, J. BURŠA, J. ŠUMBERA, J. PÁSEK, M.

Original Title

Effect of Transmural Differences in Excitation-Contraction Delay and Contraction Velocity on Left Ventricle Isovolumic Contraction: A Simulation Study

Type

journal article in Web of Science

Language

English

Original Abstract

Recent studies have shown that left ventricle (LV) exhibits considerable transmural differences in active mechanical properties induced by transmural differences in electrical activity, excitation-contraction coupling, and contractile properties of individual myocytes. It was shown that the time between electrical and mechanical activation of myocytes (electromechanical delay: EMD) decreases from subendocardium to subepicardium and, on the contrary, the myocyte shortening velocity (MSV) increases in the same direction. To investigate the physiological importance of this inhomogeneity, we developed a new finite element model of LV incorporating the observed transmural gradients in EMD and MSV. Comparative simulations with the model showed that when EMD or MSV or both were set constant across the LV wall, the LV contractility during isovolumic contraction (IVC) decreased significantly ((/)max was reduced by 2 to 38% and IVC was prolonged by 18 to 73%). This was accompanied by an increase of transmural differences in wall stress.These results suggest that the transmural differences in EMD and MSV play an important role in physiological contractility of LV by synchronising the contraction of individual layers of ventricular wall during the systole. Reduction or enhancement of these differences may therefore impair the function of LV and contribute to heart failure.

Keywords

left ventricle; isovolumic contraction; transmural heterogeneity; finite element model

Authors

VAVERKA, J.; BURŠA, J.; ŠUMBERA, J.; PÁSEK, M.

Released

10. 5. 2018

Publisher

Hindawi

Location

London, United Kingdom

ISBN

2314-6141

Periodical

BioMed Research International

Year of study

2018

Number

2018

State

United States of America

Pages from

1

Pages to

10

Pages count

10

URL

http://dx.doi.org/10.1155/2018/4798512

Full text in the Digital Library

http://hdl.handle.net/11012/72424

BibTex

@article{BUT147339,
  author="Jiří {Vaverka} and Jiří {Burša} and Josef {Šumbera} and Michal {Pásek}",
  title="Effect of Transmural Differences in Excitation-Contraction Delay and Contraction Velocity on Left Ventricle Isovolumic Contraction: A Simulation Study",
  journal="BioMed Research International",
  year="2018",
  volume="2018",
  number="2018",
  pages="1--10",
  doi="10.1155/2018/4798512",
  issn="2314-6141",
  url="http://dx.doi.org/10.1155/2018/4798512"
}