Publication result detail

Molecular biology of beta-estradiol-estrogen receptor complex binding to estrogen response element and the effect on cell proliferation

HEGER, Z.; ZÍTKA, O.; KŘÍŽKOVÁ, S.; BEKLOVÁ, M.; KIZEK, R.; ADAM, V.

Original Title

Molecular biology of beta-estradiol-estrogen receptor complex binding to estrogen response element and the effect on cell proliferation

English Title

Molecular biology of beta-estradiol-estrogen receptor complex binding to estrogen response element and the effect on cell proliferation

Type

WoS Article

Original Abstract

Group of estrogen pollutants, where the highest estrogen activity is reported at estradiol, is characterized by the fact that even at very low concentrations have potential to cause xenoestrogenic effects. During exposure of excessive amounts of estradiols may be produced undesirable effects resulting in the feminization of males of water organisms. The presence of estradiols in drinking water implies also a risk for the human population in the form of cancers of endocrine systems, abnormalities in reproduction or dysfunctions of neuronal and immune system. Currently, the research is focused mainly to uncover the relationship between the estrogen receptors binding affinity with an estrogen response element and estradiol. In this review we summarized facts about molecular biological principles of beta estradiol-estrogen receptor complex binding with estrogen response element and its successive effect on cancer genes expression.

English abstract

Group of estrogen pollutants, where the highest estrogen activity is reported at estradiol, is characterized by the fact that even at very low concentrations have potential to cause xenoestrogenic effects. During exposure of excessive amounts of estradiols may be produced undesirable effects resulting in the feminization of males of water organisms. The presence of estradiols in drinking water implies also a risk for the human population in the form of cancers of endocrine systems, abnormalities in reproduction or dysfunctions of neuronal and immune system. Currently, the research is focused mainly to uncover the relationship between the estrogen receptors binding affinity with an estrogen response element and estradiol. In this review we summarized facts about molecular biological principles of beta estradiol-estrogen receptor complex binding with estrogen response element and its successive effect on cancer genes expression.

Keywords

estradiol; estrogen response element; estrogen receptor; ligand binding domain; DNA binding domain

Key words in English

estradiol; estrogen response element; estrogen receptor; ligand binding domain; DNA binding domain

Authors

HEGER, Z.; ZÍTKA, O.; KŘÍŽKOVÁ, S.; BEKLOVÁ, M.; KIZEK, R.; ADAM, V.

RIV year

2018

Released

01.12.2013

ISBN

0172-780X

Periodical

NEUROENDOCRINOLOGY LETTERS

Volume

34

Number

2

State

Kingdom of Sweden

Pages from

123

Pages to

129

Pages count

7

BibTex

@article{BUT142340,
  author="Zbyněk {Heger} and Ondřej {Zítka} and Soňa {Křížková} and Miroslava {Beklová} and René {Kizek} and Vojtěch {Adam}",
  title="Molecular biology of beta-estradiol-estrogen receptor complex binding to estrogen response element and the effect on cell proliferation",
  journal="NEUROENDOCRINOLOGY LETTERS",
  year="2013",
  volume="34",
  number="2",
  pages="123--129",
  issn="0172-780X"
}